Luolab in Sichuan University

1. Zhang, J.; Luo, B.;  Sui, J.;  Qiu, Z.; Huang, J.;  Yang, T.; Luo, Y., IMP075 targeting ClpP for colon cancer therapy in vivo and in vitro. Biochem Pharmacol 2022, 204, 115232.

2. Zhang, J.; Qiao, W.; Luo, Y., Mitochondrial quality control proteases and their modulation for cancer therapy. Med Res Rev 2022.

3. Huang, J.; Zhang, J.;  Luo, B.;  Qiao, W.; Qiu, Z.;  Song, R.;  Dai, Z.; Sui, J.;  Xu, X.;  Ruan, S.; Li, C.;  Luo, Y.; Yang, T., Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo. J Med Chem 2022, 65 (11), 7629-7655.

4. Song, R.; Qiao, W.;  He, J.;  Huang, J.; Luo, Y.; Yang, T., Proteases and Their Modulators in Cancer Therapy:Challenges and Opportunities. J Med Chem 2021, 64 (6), 2851-287

1. Zhang, J.; Qiao, W.; Luo, Y., Mitochondrial quality control proteases and their modulation for cancer therapy. Med Res Rev 2022.

2. Zhang, J.;  Luo, B.; Sui, J.;  Qiu, Z.;  Huang, J.; Yang, T.; Luo, Y., IMP075 targeting ClpP for colon cancer therapy in vivo and in vitro. Biochem     Pharmacol 2022, 204, 115232.

3. Huang, J.;  Zhang, J.; Luo, B.;  Qiao, W.;  Qiu, Z.; Song, R.;  Dai, Z.;  Sui, J.; Xu, X.;  Ruan, S.;  Li, C.; Luo, Y.; Yang, T., Discovery of a Novel     Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo. J Med Chem 2022, 65 (11), 7629-7655.

4. Li, C.; Zhou, Y.;  Xu, J.;  Zhou, X.; Huang, Z.;  Zeng, T.;  Yang, X.; Tao, L.;  Gou, K.;  Zhong, X.; Chen, Q.;  Luo, Y.; Zhao, Y., A novel series of teriflunomide derivatives as orally active inhibitors of human dihydroorotate dehydrogenase for the treatment of colorectal carcinoma. Eur J Med Chem 2022, 238, 114489.

5. Li, C.;  Zhou, Y.; Xu, J.;  Zhou, X.;  Liu, S.; Huang, Z.;  Qiu, Z.;  Zeng, T.; Gou, K.;  Tao, L.;  Zhong, X.; Yang, X.;  Zhou, Y.;  Su, N.; Chen, Q.;  Zhao, Y.; Luo, Y., Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffold. Eur J Med Chem 2022, 243, 114737.

6. Li, C.;  Liu, S.; Dong, B.;  Li, C.;  Jian, L.; He, J.;  Zeng, J.;  Zhou, Q.; Jia, D.;  Luo, Y.; Sun, Q., Discovery and Mechanistic Study of Mycobacterium tuberculosis PafA Inhibitors. J Med Chem 2022, 65 (16), 11058-11065.

7. Lei, Y.;  An, Q.; Shen, X. F.;  Sui, M.;  Li, C.; Jia, D.;  Luo, Y.; Sun, Q., Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1. J Med Chem 2021, 64 (10), 6596-6607.

8. Song, R.;  Qiao, W.; He, J.;  Huang, J.;  Luo, Y.; Yang, T., Proteases and Their Modulators in Cancer Therapy: Challenges and Opportunities. J Med Chem 2021, 64(6), 2851-2877.

9. Chungen Li, Xiaowei Yang, Yuan Luo, Huan Liu, Xi Zhong, Xia Zhou, Ting Zeng, Lei Tao, Yue Zhou, Kun Gou, Xinyu Yang, Xiaocong Liu, Qiang Chen, Ying lan Zhao, Youfu Luo. Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment. J Med Chem. 2021 Dec 23;64(24):18175-18192.

10. Jing Sui, Wenliang Qiao, Xinrong Xiang, Youfu Luo. Epigenetic changes in Mycobacterium tuberculosis and its host provide potential targets or biomarkers for drug discovery and clinical diagnosis. Pharmacol Res. 2022 Mar 29;179:106195. doi: 10.1016/j.phrs.2022.106195.

11. Xinrong Xiang, Rui Bao, Yu Wu, Youfu Luo. Targeting mitochondrial proteases for therapy of acute myeloid leukaemia. Br J Pharmacol. 2022 Mar 30. doi: 10.1111/bph.15844.

12. Song Liu, Wenliang Qiao, Qingxiang Sun, Youfu Luo. Chromosome Region Maintenance 1 (XPO1/CRM1) as an Anticancer Target and Discovery of Its Inhibitor. J Med Chem 2021. PMID: 34669417 DOI: 10.1021/acs.jmedchem.1c01145.

13. Luo B, Ma Y, Zhou Y, Zhang N, Luo Y. Human ClpP protease, a promising therapy target for diseases of mitochondrial dysfunction. Drug Discovery Today 2021 S1359-6446(21)00034-9. PMID: 33460621 DOI:10.1016/j.drudis.2021.01.007  

14. Zhang L, He J, Bai L,  Ruan S, Yang T, Luo Y. Ribosome-targeting antibacterial agents: Advances, challenges, and opportunities. Med Res Rev

2021. PMID:33501747 DOI: 10.1002/med.21780

15. An Q, Li C, Chen Y, Deng Y, Yang T, Luo Y. Repurposed drug candidates for antituberculosistherapy. Eur J Med Chem 2020, 192, 112175. PMID: 32126450 DOI:10.1016/j.ejmech.2020.112175

16. Ju Y, He L, Zhou Y, Yang T, Sun K,  Song R, Yang Y, Li C, Sang Z, Bao R, Luo Y. Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo. J Med Chem 2020, 63 (6), 3104-3119. PMID: 32031798

DOI:10.1021/acs.jmedchem.9b01746.

17. Zuo Z, Liu X, Qian X, Zeng T, Sang N, Liu H, Zhou Y, Tao L, Zhou X, Su N, Yu Y, Chen Q, Luo Y, Zhao Y. Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production. J Med Chem 2020, 63 (14), 7633-7652. PMID: 32496056 DOI: 10.1021/acs.jmedchem.0c00512.

18. Ke Sun, Yuan Ju, Chuan Chen, Peng Zhang, Erica Sawyer, Youfu Luo, Jia Geng. Single‐Molecule Interaction of Peptides with a Biological Nanopore for Identification of of Protease Activity. Small Methods.2020, doi: 10.1002/smtd.201900892

19. Zitai Sang, Yongping Lu, Yuanzheng Zhou,Yuan Ju, Qi An, Silan Shen, Jianyou Shi, Jun He, Tao Yang, Youfu Luo. Efficient discovery of novel antimicrobials through integration of synthesis and testing in crude ribosome extract. Chemical Communication 55, 5886–5889 (2019).

PMID: 31041938 DOI: 10.1039/c9cc00144a

20. Pingxian Liu, Yang Yang, Yunxiang Tang,Tao Yang, Zitai Sang, Zhiyong Liu, Tianyu Zhang, Youfu Luo. Design and synthesis of novel pyrimidine derivatives as potent antitubercular agents. European Journal of Medicinal Chemistry 163,169–182 (2019). PMID: 30508666 DOI:10.1016/j.ejmech.2018.11.054

21. Chungen Li, Caili Chen, Qi An, Tao Yang,Zitai Sang, Yang Yang, Yuan Ju, Aiping Tong, Youfu Luo. A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3). European Journal of Medicinal Chemistry 162, 543–554 (2019). PMID: 30472602 DOI: 10.1016/j.ejmech.2018.10.067

22. Chenzi Zhang, Xinyi Kuang, Yuanzheng Zhou, Xian Peng, Qiang Guo, Tao Yang, Xuedong Zhou, Youfu Luo, Xin Xu. A novel small molecule, ZY354, inhibits dental caries-associated oral biofilms. Antimicrobial Agents and Chemotherapy 63, (2019). PMID: 30858201 DOI:10.1128/AAC.02414-18